Synopsis - My voyage in heterocyclic research started with simple diazines. Diazines are family of heterocyclic compounds, containing two nitrogen atoms at various positions. Examples of simple diazines are pyrimidines, with two nitrogen atoms at 1, 3 positions, pyrazines, with nitrogen atoms at 1, 4 positions and pyridazines, nitrogen atoms at 1, 2 positions. The structural unit of pyrazine and pyrimidine, for example is found in many natural products. The pyrimidine ring system has wide occurrence in nature, either as substituted and/or ring fused compounds, for example in the nucleotides, thiamine (vitamin B1) and alloxan. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrazine on the other hand, is also found as flavour constituents in peas, coffee, capsicum peppers and wines. Pyrazine and pyrimidine fuse with either benzene or another heterocycle to form fused-ring systems, for example purines, quinoxalines, thiadiazole, etc. Our team embarked in synthesizing fluorescent derivatives of pyrimidines, pyrazines, quinoxalines, etc., and their metal complexes. Our work continues with synthesis of biologically active systems such as derivatives of imidazolium, benzimidazolium, 1, 2, 4-triazole and 1, 3, 4-oxadiazole.
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